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Prevalence of sensitization to airborne allergens, unlike that to dietary allergens, has increased over a long period of time. during or immediately after World War II. The lowest prevalence of asthma and sensitization to dietary allergens was detected in those born in 1943–46, i.e. The proportion of those with diagnosed asthma differed significantly (χ 2=13.45, P=0.004) across the birth cohorts. Similar progression was not seen in sensitization to dietary allergens. The proportion of subjects with detectable IgE antibodies against aeroallergens increased consistently from the oldest to the youngest birth cohorts χ 2 trend=56.809, P<0.0001.
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A questionnaire elicited information on symptoms, allergic diseases and medication. Serum total and specific IgE concentrations against aeroallergens and dietary allergens were determined. We studied four groups of 100 subjects each (at ages 7, 27, 47 and 67 years), representing those born in 1990, 1963–66, 1943–46 and in 1923–26, respectively. To evaluate how the prevalence of atopic disease has changed in terms of detectable sensitization to aeroallergens and dietary allergens in a cross-sectional comparison of subjects from birth cohorts more than 60 years apart. The precise turning point for the epidemic and the antigens responsible for it remain obscure. Increased prevalence of allergic diseases in western societies has been described as an epidemic.
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